Molecular characterization of WDCP, a novel fusion partner for the anaplastic lymphoma tyrosine kinase ALK.
作者： NORIKO YOKOYAMA , W. TODD MILLER
DOI: 10.3892/BR.2014.374
关键词:
摘要: Anaplastic lymphoma kinase (ALK) is a member of the receptor tyrosine superfamily. The ALK gene site frequent mutation and chromosomal rearrangement in various types human cancers. A novel translocation was recently identified colorectal cancer between chromosome 2, open reading frame 44 (C2orf44), unknown function. As first step understanding oncogenic properties this fusion protein, C2orf44 cDNA cloned encoded protein characterized, which designated as WD repeat coiled coil containing (WDCP). C-terminal proline-rich segment WDCP shown to mediate binding Src homology 3 domain family hematopoietic cell (Hck). Co-expression with Hck lead phosphorylation WDCP. Chromatographic fractionation WDCP-containing lysates indicates that exists an oligomer mammalian cells. These results suggest that, context ALK-C2orf44 fusion, imposes oligomeric structure on constitutive activation signaling.
sci-hub.se 参考文章(19)
Rodney E. Shackelford, Moiz Vora, Kim Mayhall, James Cotelingam, ALK-rearrangements and testing methods in non-small cell lung cancer: a review. Genes & Cancer. ,vol. 5, pp. 1- 14 ,(2014) , 10.18632/GENESANDCANCER.3
D. Cussac, Nucleophosmin-anaplastic lymphoma kinase of anaplastic large-cell lymphoma recruits, activates, and uses pp60c-src to mediate its mitogenicity. Blood. ,vol. 103, pp. 1464- 1471 ,(2003) , 10.1182/BLOOD-2003-04-1038
Andres Morales La Madrid, Nicholas Campbell, Sonali Smith, Susan L. Cohn, Ravi Salgia, Targeting ALK : a promising strategy for the treatment of non-small cell lung cancer, non-Hodgkin’s lymphoma, and neuroblastoma Targeted Oncology. ,vol. 7, pp. 199- 210 ,(2012) , 10.1007/S11523-012-0227-8
Temple F Smith, Chrysanthe Gaitatzes, Kumkum Saxena, Eva J Neer, The WD repeat: a common architecture for diverse functions. Trends in Biochemical Sciences. ,vol. 24, pp. 181- 185 ,(1999) , 10.1016/S0968-0004(99)01384-5
Doron Lipson, Marzia Capelletti, Roman Yelensky, Geoff Otto, Alex Parker, Mirna Jarosz, John A Curran, Sohail Balasubramanian, Troy Bloom, Kristina W Brennan, Amy Donahue, Sean R Downing, Garrett M Frampton, Lazaro Garcia, Frank Juhn, Kathy C Mitchell, Emily White, Jared White, Zac Zwirko, Tamar Peretz, Hovav Nechushtan, Lior Soussan-Gutman, Jhingook Kim, Hidefumi Sasaki, Hyeong Ryul Kim, Seung-il Park, Dalia Ercan, Christine E Sheehan, Jeffrey S Ross, Maureen T Cronin, Pasi A Jänne, Philip J Stephens, Identification of new ALK and RET gene fusions from colorectal and lung cancer biopsies Nature Medicine. ,vol. 18, pp. 382- 384 ,(2012) , 10.1038/NM.2673
Bengt Hallberg, Ruth H. Palmer, Mechanistic insight into ALK receptor tyrosine kinase in human cancer biology Nature Reviews Cancer. ,vol. 13, pp. 685- 700 ,(2013) , 10.1038/NRC3580
Christopher Greenman, Philip Stephens, Raffaella Smith, Gillian L. Dalgliesh, Christopher Hunter, Graham Bignell, Helen Davies, Jon Teague, Adam Butler, Claire Stevens, Sarah Edkins, Sarah O’Meara, Imre Vastrik, Esther E. Schmidt, Tim Avis, Syd Barthorpe, Gurpreet Bhamra, Gemma Buck, Bhudipa Choudhury, Jody Clements, Jennifer Cole, Ed Dicks, Simon Forbes, Kris Gray, Kelly Halliday, Rachel Harrison, Katy Hills, Jon Hinton, Andy Jenkinson, David Jones, Andy Menzies, Tatiana Mironenko, Janet Perry, Keiran Raine, Dave Richardson, Rebecca Shepherd, Alexandra Small, Calli Tofts, Jennifer Varian, Tony Webb, Sofie West, Sara Widaa, Andy Yates, Daniel P. Cahill, David N. Louis, Peter Goldstraw, Andrew G. Nicholson, Francis Brasseur, Leendert Looijenga, Barbara L. Weber, Yoke-Eng Chiew, Anna deFazio, Mel F. Greaves, Anthony R. Green, Peter Campbell, Ewan Birney, Douglas F. Easton, Georgia Chenevix-Trench, Min-Han Tan, Sok Kean Khoo, Bin Tean Teh, Siu Tsan Yuen, Suet Yi Leung, Richard Wooster, P. Andrew Futreal, Michael R. Stratton, Patterns of somatic mutation in human cancer genomes Nature. ,vol. 446, pp. 153- 158 ,(2007) , 10.1038/NATURE05610
Bruce J. Mayer, Michael J. Eck, SH3 Domains: Minding your p's and q's Current Biology. ,vol. 5, pp. 364- 367 ,(1995) , 10.1016/S0960-9822(95)00073-X
S. Morris, M. Kirstein, M. Valentine, K. Dittmer, D. Shapiro, D. Saltman, A. Look, Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma Science. ,vol. 263, pp. 1281- 1284 ,(1994) , 10.1126/SCIENCE.8122112
James G Bilsland, Alan Wheeldon, Andrew Mead, Petr Znamenskiy, Sarah Almond, Kerry A Waters, Matthew Thakur, Vahri Beaumont, Timothy P Bonnert, Robert Heavens, Paul Whiting, George McAllister, Ignacio Munoz-Sanjuan, None, Behavioral and neurochemical alterations in mice deficient in anaplastic lymphoma kinase suggest therapeutic potential for psychiatric indications Neuropsychopharmacology. ,vol. 33, pp. 685- 700 ,(2008) , 10.1038/SJ.NPP.1301446