"Fishing" for endothelial microRNA functions and dysfunction.

摘要: Abstract MicroRNAs (e.g. miRNAs), endogenously expressed small non-coding RNAs, control gene expression by regulating target messenger RNA at post-transcriptional level. Recent studies have identified a specific role for microRNAs as key regulators of vascular function and dysfunction. The zebrafish ( Danio rerio ) system is useful model to study endothelial cell homeostasis during normal pathological conditions. In this review, we describe how the becoming tool their genes in smooth muscle cells both Finally, also discuss many ways manipulate miRNAs levels therapeutic approaches.