The effect of differing patterns of childhood body mass index gain on adult physiology in American Indians

摘要: Objective Identifying groups of individuals with similar patterns body mass index (BMI) change during childhood may increase understanding the relationship between BMI and adult health. Methods Discrete classes z-score were determined in 1,920 American Indian children at least four non diabetic health examinations ages 2 18 years using latent class trajectory analysis. In subsets subjects, data available for melanocortin-4 receptor (MC4R) sequencing; utero exposure to type diabetes (T2D); or, as adults, oral glucose tolerance tests, onset T2D, or composition. Results Six separate identified. Individuals a more modern birth year, an MC4R mutation, T2D clustered two high increasing chronic overweight z-scores (P < 0.0001). The predicted percent fat (P < 0.0001, partial r2 = 0.18 adjusted covariates). There was greater risk independent from BMI, three (lean overweight, increasing, z-scores) compared leanest (respectively: HRR= 3.2, P = 0.01; 6.0, P = 0.0003; 11.6, P < 0.0001). Conclusions Distinct associate adiposity impact T2D.