Cerebral blood flow measured by arterial spin labeling MRI at resting state in normal aging and Alzheimer's disease.

摘要: Arterial spin labeling (ASL) magnetic resonance imaging uses arterial blood water as an endogenous tracer to measure cerebral flow (CBF). In this review, based on ASL studies in the resting state, we discuss state-of-the-art technical and data processing improvements ASL, CBF changes normal aging, mild cognitive impairment (MCI), Alzheimer's disease (AD), other types of dementia. We propose that vascular AD risk factors should be considered when evaluating validated biomarkers used inclusion criteria or covariates MCI AD. With hardware experimental design, is proving increasingly promising tool for exploring pathogenetic mechanisms, early detection, monitoring progression pharmacological response, differential diagnosis