Hipopara-Red, Real Life Experience in 322 Patients With Hypoparathyroidism.

摘要: Context Hypoparathyroidism is a rare disease and, as such, its natural history, long-term complications, and correct clinical management remain unclear. Objective To describe the history characteristics of disease. Design Setting present retrospective observational analysis from 7 specialized centers in Buenos Aires, Argentina. Patients Chronic hypoparathyroid patients followed-up between 1985 December 2018. Main Outcome Measures Data on demographics, etiology, biochemical parameters, dual-energy x-ray absorptiometry (DXA) values, treatment doses were collected. Results A total 322 subjects with chronic hypoparathyroidism included; 85.7% female, mean age was 55.2 ± 16.8 years, at diagnosis 43.8 ± 16.8 years. Prevalence surgical 90.7%, most common causes being thyroid carcinoma benign hypocalcemia requiring hospitalization 25.7% whole group 4.3% who had seizures. Overall, 40.9% our reported least 1 neuromuscular symptom. Renal insufficiency 22.4% significantly associated (P < 0.0001). Hyperphosphatemia 42% patients. severe hypocalcemia, paresthesias, tetany, ganglia calcifications, seizures, cataracts higher nonsurgical Conclusion Although these by experienced physicians, heterogeneous probably insufficient to assess all potential complications this Almost 70% study's met experts' indications for considering use rhPTH 1-84. Being aware fact 1st step improving medical future.