Epidermal growth factor 61 A/G polymorphism and uterine cervical cancer.

摘要: Cervical cancer, the second most common malignancy in women worldwide, is almost invariably associated with infection by human papillomavirus (HPV). However, although many are infected high-risk types of HPV, only a subset will ever develop cervical cancer. Therefore, host genetic factor may play role carcinogenesis. Alterations epidermal growth receptor (EGFR) events we hypothesized that functional polymorphism 5′ untranslated region (EGF) gene, natural ligand EGFR, carcinogenesis and tumor invasiveness. We assessed possible association between EGF +61 A/G cancer risk hospital-based case–control study among 337 Korean (168 cases, 169 age-matched controls). The frequencies allele genotype were not different cases controls. observed increasing trend lymph node metastasis from A/A homozygous toward G/G genotype. did find any evidence was individual susceptibility it statistically significant, according to suggests possibility variance expression be also confirmed there exists striking ethnic heterogeneity Caucasian East Asian population