Heparin Blunts Endotoxin-Induced Coagulation Activation

摘要: Background—Lipopolysaccharide (LPS) is a major trigger of sepsis-induced disseminated intravascular coagulation (DIC) via the tissue factor (TF)/factor VIIa–dependent pathway coagulation. Experimental endotoxemia has been used repeatedly to explore this complex pathophysiology, but little known about effects clinically anticoagulants in setting. Therefore, we compared with placebo unfractionated heparin (UFH) and low-molecular-weight (LMWH) on LPS-induced Methods Results—In randomized, double-blind, placebo-controlled trial, 30 healthy male volunteers received LPS 2 ng/kg IV followed by bolus-primed continuous infusion UFH, LMWH, or placebo. In group, activation caused marked increases plasma levels prothrombin fragment F1+2 (P<0.01) polymerized soluble fibrin, termed thrombus precursor protein (TpP; P<0.01); TF-positive monocytes doubled response LPS, whereas activated VII sli...