摘要: Myelodysplastic syndromes (MDS) are clonal diseases of the elderly characterized by chronic cytopenias, dysplasia and a variable risk progression to acute myeloid leukemia (AML). Aberrant methylation tumor-suppressor gene promoters has been established for many years recently tracked most immature cells MDS, suggesting that these alterations drivers MDS pathogenesis. In recent years, recurrent somatic mutations in genes encoding proteins involved DNA demethylation covalent histone modifications have reported malignancies, including MDS. Whole-genome epigenetic profiles also emerging. parallel with advances molecular pathogenesis clinical trials hypomethylating agents (HMAs) as mainstay therapy advanced forms disease. this review, we summarize current understanding machinery regulation, discuss how arise contribute its then mode action HMAs
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sci-hub.se 参考文章(128)
Elizabeth E. Cameron, Kurtis E. Bachman, Sanna Myöhänen, James G. Herman, Stephen B. Baylin, Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer Nature Genetics. ,vol. 21, pp. 103- 107 ,(1999) , 10.1038/5047
Yogen Saunthararajah, Quteba Ebrahem, Soledad Negrotto, Reda Mahfouz, Kevin Link, Zhenbo Hu, Xiaorong Gu, Anjali Advani, Matt Kalaycio, Ronald Sobecks, Mikkael Sekeres, Edward Copelan, Tomas Radivoyevitch, Jaroslaw Maciejewski, James C. Mulloy, Kwok-Peng Ng, p53 independent epigenetic-differentiation treatment in xenotransplant models of acute myeloid leukemia Nature Precedings. pp. 1- 1 ,(2011) , 10.1038/NPRE.2011.5780.1
Thomas Ernst, Andrew J Chase, Joannah Score, Claire E Hidalgo-Curtis, Catherine Bryant, Amy V Jones, Katherine Waghorn, Katerina Zoi, Fiona M Ross, Andreas Reiter, Andreas Hochhaus, Hans G Drexler, Andrew Duncombe, Francisco Cervantes, David Oscier, Jacqueline Boultwood, Francis H Grand, Nicholas C P Cross, Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders Nature Genetics. ,vol. 42, pp. 722- 726 ,(2010) , 10.1038/NG.621
Tamer E. Fandy, James G. Herman, Patrick Kerns, Anchalee Jiemjit, Elizabeth A. Sugar, Si-Ho Choi, Allen S. Yang, Timothy Aucott, Tianna Dauses, Rosalie Odchimar-Reissig, Jonathan Licht, Melanie J. McConnell, Chris Nasrallah, Marianne K. H. Kim, Weijia Zhang, Yezou Sun, Anthony Murgo, Igor Espinoza-Delgado, Katharine Oteiza, Ibitayo Owoeye, Lewis R. Silverman, Steven D. Gore, Hetty E. Carraway, Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies Blood. ,vol. 114, pp. 2764- 2773 ,(2009) , 10.1182/BLOOD-2009-02-203547
A Mims, A R Walker, X Huang, J Sun, H Wang, R Santhanam, A M Dorrance, C Walker, P Hoellerbauer, S S Tarighat, K K Chan, R B Klisovic, D Perrotti, M A Caligiuri, J C Byrd, C-S Chen, L James Lee, S Jacob, K Mrózek, C D Bloomfield, W Blum, R Garzon, S Schwind, G Marcucci, Increased anti-leukemic activity of decitabine via AR-42-induced upregulation of miR-29b: a novel epigenetic-targeting approach in acute myeloid leukemia. Leukemia. ,vol. 27, pp. 871- 878 ,(2013) , 10.1038/LEU.2012.342
Jumpei Yamazaki, Rodolphe Taby, Aparna Vasanthakumar, Trisha Macrae, Kelly R. Ostler, Lanlan Shen, Hagop M. Kantarjian, Marcos R. Estecio, Jaroslav Jelinek, Lucy A. Godley, Jean-Pierre J. Issa, Effects of TET2 mutations on DNA methylation in chronic myelomonocytic leukemia Epigenetics. ,vol. 7, pp. 201- 207 ,(2012) , 10.4161/EPI.7.2.19015
G W Rhyasen, D T Starczynowski, Deregulation of microRNAs in myelodysplastic syndrome. Leukemia. ,vol. 26, pp. 13- 22 ,(2012) , 10.1038/LEU.2011.221
Ying Jiang, Andrew Dunbar, Lukasz P. Gondek, Sanjay Mohan, Manjot Rataul, Christine O'Keefe, Mikkael Sekeres, Yogen Saunthararajah, Jaroslaw P. Maciejewski, Aberrant DNA methylation is a dominant mechanism in MDS progression to AML Blood. ,vol. 113, pp. 1315- 1325 ,(2009) , 10.1182/BLOOD-2008-06-163246
Mrinal Y. Shah, Aparna Vasanthakumar, Natalie Y. Barnes, Maria E. Figueroa, Anna Kamp, Christopher Hendrick, Kelly R. Ostler, Elizabeth M. Davis, Shang Lin, John Anastasi, Michelle M. Le Beau, Ivan P. Moskowitz, Ari Melnick, Peter Pytel, Lucy A. Godley, DNMT3B7, a Truncated DNMT3B Isoform Expressed in Human Tumors, Disrupts Embryonic Development and Accelerates Lymphomagenesis Cancer Research. ,vol. 70, pp. 5840- 5850 ,(2010) , 10.1158/0008-5472.CAN-10-0847
Chun-Xiao Song, Keith E. Szulwach, Qing Dai, Ye Fu, Shi-Qing Mao, Li Lin, Craig Street, Yujing Li, Mickael Poidevin, Hao Wu, Juan Gao, Peng Liu, Lin Li, Guo-Liang Xu, Peng Jin, Chuan He, Genome-wide Profiling of 5-Formylcytosine Reveals Its Roles in Epigenetic Priming Cell. ,vol. 153, pp. 678- 691 ,(2013) , 10.1016/J.CELL.2013.04.001