A genomic approach to investigate expression profiles in Slovenian patients with gastric cancer.

摘要: Despite its decreasing frequency in developed countries, gastric cancer remains a significant health burden. The aim of the present study was to construct cDNA libraries and analyze differentially expressed genes related this disease. Gene expression profiles were generated with suppressive subtraction hybridization (SSH). We constructed eight SSH libraries, four representing up-regulated down-regulated tumor tissues. Our approach revealed that several are abnormally cancer. also identified global deregulation pathways involved maintenance normal homeostasis. results support view that, as result complex pathogenesis, diversity genomic aberrations multiplicity carcinogenic causes, cannot be reduced single molecule. may contribute new insight into molecular aspects disease prove advantageous for future development therapeutic targets diagnostic markers.