Common Antigenic Determinants on Human Melanoma, Glioma, Neuroblastoma, and Sarcoma Cells Defined with Monoclonal Antibodies

摘要: Antigenic determinants that are common to melanomas, gliomas, neuroblastomas, and sarcomas but minimally or not detectably expressed by adult tissues were defined with monoclonal antibodies. Quantitative absorption of antibody (Ab 165) followed testing on antigen-positive UCLA-SO-M14 melanoma cells did demonstrate antigenic determinant (Ag in brain, lung, liver, kidney, intestine, adrenal, muscle. Absorption Ab 376 demonstrated Ag lung minimal no antigen other tissues. Both antigens associated a variety fetal Assessment 28 human tumor cell lines the 131I-staphylococcal Protein A-binding test 165 reacted strongly melanomas gliomas weakly sarcomas. Neither these antibodies appreciably carcinoma teratoma lines. noncultured tumors sarcomas, neuroblastomas can have greater quantities vivo than do normal Qualitative quantitative heterogeneity within positive classes was for both cultured tumors. The differences expression between neoplastic suggest potential value immunodiagnosis possibly immunotherapy.