Acute effects of ethanol on the transfer of nicotine and two dietary carcinogens in human placental perfusion
作者： Jenni Veid , Vesa Karttunen , Kirsi Myöhänen , Päivi Myllynen , Seppo Auriola
DOI: 10.1016/J.TOXLET.2011.06.014
关键词:
摘要: Many mothers use, against instructions, alcohol during pregnancy. Simultaneously are exposed to a wide range of other environmental chemicals. These chemicals may also harm the developing fetus, because almost all toxic compounds can go through human placenta. Toxicokinetic effects ethanol on transfer placenta have not been studied before. It is known that has lytic properties and increases permeability fluidity cell membranes. We three different toxins: nicotine, PhIP (2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine) NDMA (N-nitrosodimethylamine) in placental perfusion. tested breast cancer adenocarcinoma line MCF-7 whether affects ABCG2/BCRP, which major transporter found comparable antipyrine, points passive diffusion as mechanism. Unexpectedly, had no statistically significant effect compounds. Neither did inhibit function ABCG2/BCRP. experiments represent only acute exposure chronic remains be studied.
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