Activation of serotonin 3 receptors changes in vivo auditory responses in the mouse inferior colliculus

摘要: Metabotropic serotonin receptors such as 5-HT1A and 5-HT1B shape the level, selectivity, timing of auditory responses in inferior colliculus (IC). Less is known about effects ionotropic 5-HT3 receptors, which are cation channels that depolarize neurons. In present study, influence receptor on vivo was explored by locally iontophoresing a agonist antagonists onto single neurons recorded extracellularly mice. Three main findings emerge from these experiments. First, activation can either facilitate or suppress responses, but response suppressions not consistent with presynaptic GABAergic Both facilitations less pronounced high precision latency, suggesting functional differences role for different classes neuron. Finally, vary across repetition rate within subset neurons, sometimes varies level activity. These contribute to view an important component serotonergic infrastructure IC, complex neuron-selective.