Use of 5-fluorouracil and survival in patients with microsatellite-unstable colorectal cancer.

摘要: Abstract Background & Aims: 5-Fluorouracil improves mortality in stage III colorectal cancer patients. In vitro studies suggest that microsatellite instability influences cell survival after 5-fluorouracil treatment. We investigated the influence of patients with instability-high tumors. Methods: collected data and tumors on 204 consecutive II from registries at University California Veterans Administration hospitals San Diego, California, 1982 to 1999. Archival DNA was extracted, assessed by National Cancer Institute-recommended markers. Cox proportional hazard modeling used determine associations for treatment status. Results: identified 36 (17.6%) 168 non-microsatellite (82.4%). Microsatellite were significantly associated proximal colon location, presence mucin, surrounding lymphoid reaction. Univariate multivariate analyses showed no difference between groups (hazard ratio, 1.04; P = 0.88). Dichotomized use 5-fluorouracil, there increased risk death who received adjuvant chemotherapy 2.02; 0.02). However, benefit different groups. Patients had better compared not treated ( 0.52). Conclusions: There is improved 5-fluorouracil-based does extend The status a patient's may indicate differences chemosensitivity; this consistent studies.