Release of vasoactive peptides in the extracerebral circulation of humans and the cat during activation of the trigeminovascular system.

摘要: The trigeminal ganglion was activated, in humans by thermocoagulation as part of the treatment neuralgia and cats electrical stimulation, blood samples were taken from external jugular vein for estimates plasma levels substance P calcitonin gene-related peptide (CGRP). In those patients who noted at time coagulation to have flushed there marked elevations local (cranial) both peptides. However, nonflushing no changes observed. Parallel experiments cat revealed that P-like CGRP-like immunoreactivity increased during stimulation ganglion. observation elevation after activation nociceptive afferent system head provides new insights into a putative role peptides pathophysiology migraine cluster headache, suggests areas possible therapeutic intervention.