Radiochemotherapy induces a favourable tumour infiltrating inflammatory cell profile in head and neck cancer.
作者： M. Büttner , G.G. Grabenbauer , E. Nkenke , R. Fietkau , D. Lubgan
DOI: 10.1016/J.ORALONCOLOGY.2012.01.024
关键词:
摘要: Summary Head and neck squamous cell cancers (HNSSC) generate an immune-suppressive micro-environment by a specific pattern of tumour infiltrating inflammatory cells. The aim our study was to evaluate the impact radiochemotherapy on numbers composition cells its influence outcome. Fifty-eight patients suffering from oral cavity cancer were studied, whose therapy consisted concurrent followed surgery. Numbers ratios compared prior after radiochemotherapy. Intraepithelial stromal location analysed separately. Infiltration CD3 + , CD4 CD25 FoxP3 CD8 Granzyme B CD20 CD68 predominated in peritumoural compartment, whereas CD1a dendritic found more frequently intraepithelial compartment. Neoadjuvant treatment associated with general decrease both compartments. cytotoxic decreased only slightly RCT. In contrast, regulatory T pronounced T-cell/FoxP3 ratio increased 2- 3-fold compartments, respectively. Patients high numbers, had better disease free survival. Concurrent carcinoma shown drive direction which is supposed be prognostically favourable.
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