Frequent epidermal growth factor receptor gene mutations in malignant pleural effusion of lung adenocarcinoma
作者： S-G. Wu , C-H. Gow , C-J. Yu , Y-L. Chang , C-H. Yang
DOI: 10.1183/09031936.00167407
关键词:
摘要: Malignant pleural effusions (MPEs) are often observed in lung cancer, especially adenocarcinoma. Epidermal growth factor receptor (EGFR) gene mutations usually detected The purpose of the present study was to investigate EGFR mutation rate MPEs Between June 2005 and December 2006, 136 from adenocarcinoma were collected for detection. In addition, between April 2001 November 2004, 91 surgically resected specimens patients without assessed mutation. significantly higher with than (68.4% versus 50.5%). not associated sex, smoking history, age or cancer stage. By multivariate analysis, an <65 yrs, never smoking, Eastern Cooperative Oncology Group performance status 0-1, a longer overall survival MPEs. malignant related had epidermal whom taken. tyrosine kinase inhibitors may be treatment choice east Asia.
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