Cognitive and behavioral problems in children with neurofibromatosis type 1: challenges and future directions.
作者： Katherine E Schwetye , David H Gutmann
DOI: 10.1586/14737175.2014.953931
关键词:
摘要: Cognitive and behavioral disorders affect nearly 80% of all children with the neurofibromatosis type 1 inherited cancer syndrome, are among most significant clinical manifestations for patients their families. One barriers to successful therapeutic intervention is wide spectrum phenotypic expression, ranging from visuospatial learning problems social perceptual deficits (autism). Leveraging numerous small-animal models 1, several promising targets have been identified treat learning, attention, autism phenotypes in this at-risk population. In review, we provide an up-to-date summary our current understanding these NF1, propose future research directions aimed at designing more effective approaches trials.
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