Cellular and Molecular Factors Influencing Tendon Repair

摘要: Tendons are complex connective tissues that transmit tensile forces between muscles and tendons. Tendon injuries among the most common orthopedic problems with long-term disability as a frequent consequence due to prolonged healing time. Furthermore, repair tissue is of inferior quality, predisposing patients high rates recurrence following initial injury. Coordinated cellular processes biological factors under influence mechanical loading involved in tendon our understanding these events lags behind other musculoskeletal tissues. relatively hypocellular hypovascular, little or no intrinsic regenerative capacity. Studies have documented fatty degeneration, chondrogenic dysplasia, ectopic ossification within tissue. The underlying pathogenesis for metaplastic changes compromise quality poorly understood. purpose this review compile literature reporting molecular processe...