Liquid chromatography–tandem mass spectrometry assay for the quantitation of β-dihydroartemisinin in rat plasma
作者： Jie Xing , Hong-Xia Yan , Rui-Li Wang , Li-Feng Zhang , Shu-Qiu Zhang
DOI: 10.1016/J.JCHROMB.2007.01.017
关键词:
摘要: Abstract Dihydroartemisinin (DHA) is a sesquiterpene used in the world as an antimalarial. To evaluate pharmacokinetics of dihydroartemisinin rats, sensitive and specific liquid chromatography/tandem mass spectrometric (LC–MS/MS) method was developed validated for quantitation rat plasma. For detection, Sciex API 4000 LC–MS/MS with TurboIonSpray ionization (ESI) inlet positive ion-multiple reaction monitoring (MRM) mode used. The plasma samples were pre-treated by simple liquid–liquid extraction diethyl ether. statistical evaluation this reveals excellent linearity, accuracy precision range concentrations 0.2–100.0 ng/mL. had lower limit quantification (LLOQ) 0.2 ng/mL β-dihydroartemisinin 100 μL successfully applied to characterization pharmacokinetic profile rats after oral administration.
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sci-hub.se 参考文章(13)
John K. Baker, James D. McChesney, Hsien Tao Chi, Decomposition of Arteether in Simulated Stomach Acid Yielding Compounds Retaining Antimalarial Activity Pharmaceutical Research. ,vol. 10, pp. 662- 666 ,(1993) , 10.1023/A:1018943329109
K M Trotman, J O Peggins, T G Brewer, J M Grace, A J Aguilar, Metabolism of beta-arteether to dihydroqinghaosu by human liver microsomes and recombinant cytochrome P450. Drug Metabolism and Disposition. ,vol. 26, pp. 313- 317 ,(1998)
S. Sabarinath, M. Rajanikanth, K. P. Madhusudanan, R. C. Gupta, A sensitive and selective liquid chromatographic/electrospray ionization tandem mass spectrometric assay for the simultaneous quantification of α-,β-arteether and its metabolite dihydroartemisinin in plasma, useful for pharmacokinetic studies† Journal of Mass Spectrometry. ,vol. 38, pp. 732- 742 ,(2003) , 10.1002/JMS.487
Richard K. Haynes, Ho-Wai Chan, Man-Ki Cheung, Wai-Lun Lam, May-Kei Soo, Hing-Wo Tsang, Arnd Voerste, Ian D. Williams, C-10 Ester and Ether Derivatives of Dihydroartemisinin − 10-α Artesunate, Preparation of Authentic 10-β Artesunate, and of Other Ester and Ether Derivatives Bearing Potential Aromatic Intercalating Groups at C-10 European Journal of Organic Chemistry. ,vol. 2002, pp. 113- 132 ,(2002) , 10.1002/1099-0690(20021)2002:1<113::AID-EJOC113>3.0.CO;2-N
Himanshu Naik, Daryl J. Murry, L.E. Kirsch, Lawrence Fleckenstein, Development and validation of a high-performance liquid chromatography-mass spectroscopy assay for determination of artesunate and dihydroartemisinin in human plasma. Journal of Chromatography B. ,vol. 816, pp. 233- 242 ,(2005) , 10.1016/J.JCHROMB.2004.11.042
M. Rajanikanth, K. P. Madhusudanan, R. C. Gupta, An HPLC-MS method for simultaneous estimation of α, β-arteether and its metabolite dihydroartemisinin, in rat plasma for application to pharmacokinetic study Biomedical Chromatography. ,vol. 17, pp. 440- 446 ,(2003) , 10.1002/BMC.261
Witting, Die Corallen rücksichtlich ihrer Bildung und chemischen Bestandtheile European Journal of Organic Chemistry. ,vol. 1, pp. 113- 120 ,(1832) , 10.1002/JLAC.18320010121
Kevin T Batty, Timothy ME Davis, Tran Quang Binh, Trinh Kim Anh, Kenneth F Ilett, None, Selective high-performance liquid chromatographic determination of artesunate and α- and β-dihydroartemisinin in patients with falciparum malaria Journal of Chromatography B: Biomedical Sciences and Applications. ,vol. 677, pp. 345- 350 ,(1996) , 10.1016/0378-4347(95)00428-9
J. Karbwang, K. Na-Bangchang, P. Molunto, V. Banmairuroi, K. Congpuong, Determination of artemether and its major metabolite, dihydroartemisinin, in plasma using high-performance liquid chromatography with electrochemical detection. Journal of Chromatography B: Biomedical Sciences and Applications. ,vol. 690, pp. 259- 265 ,(1997) , 10.1016/S0378-4347(96)00422-7
C Souppart, N Gauducheau, N Sandrenan, F Richard, Development and validation of a high-performance liquid chromatography-mass spectrometry assay for the determination of artemether and its metabolite dihydroartemisinin in human plasma. Journal of Chromatography B. ,vol. 774, pp. 195- 203 ,(2002) , 10.1016/S1570-0232(02)00207-6