Expression and regulation of collagenase‐3 (MMP‐13) in human malignant tumors
作者： MILAGROS BALBÍN , ALBERTO M. PENDÁS , JOSÉ A. URÍA , MARIA G. JIMÉNEZ , JOSÉ P. FREIJE
DOI: 10.1111/J.1699-0463.1999.TB01525.X
关键词:
摘要: Human collagenase-3 (MMP-13) is a matrix metalloproteinase originally identified in breast carcinomas. Recent studies have revealed that this enzyme also produced by variety of malignant tumors including head and neck carcinomas, chondrosarcomas basal cell carcinomas the skin. In all cases, expression associated with aggressive tumors. Different cytokines, growth factors tumor promoters are able to up-regulate cells or stromal surrounding epithelial cells. Functional analysis gene promoter has allowed identification AP-1 OSE-2 elements mediating, at least part, its both normal pathological conditions.
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