Na+ channels: Structure, function, and classification

摘要: The isolation and characterization of cloned Na channels have given new insights into structure-function relationships. In particular, recent mutational analyses the tetrodotoxin binding site inactivation gate begun to clarify structural basis for phenomena drug block at extracellular mouth ion-conducting pore, regulation ion conductance by gating intracellular mouth. However, much more work remains be done, particularly in regard receptors local anesthetic class drugs. This paper reviews background, some advances future direction channel studies. © 1994 Wiley-Liss, Inc.