The betaine/GABA transporter and betaine: roles in brain, kidney, and liver.

作者: Stephen A. Kempson , Yun Zhou , Niels C. Danbolt

DOI: 10.3389/FPHYS.2014.00159

关键词:

摘要: … ) and mediates cellular uptake of betaine and GABA in a sodium- and chloride-dependent … may be important in liver metabolism as a methyl donor. In fact, in the mouse the liver is the …

参考文章(203)
Barrie P. Bode, Bryan C. Fuchs, Bryan P. Hurley, Jennifer L. Conroy, Julie E. Suetterlin, Kenneth K. Tanabe, David B. Rhoads, Steve F. Abcouwer, Wiley W. Souba, Molecular and functional analysis of glutamine uptake in human hepatoma and liver-derived cells. American Journal of Physiology-gastrointestinal and Liver Physiology. ,vol. 283, ,(2002) , 10.1152/AJPGI.00031.2002
Judith Blaine, Bailey M. Anderson, Moshe Levi, Stephen A. Kempson, Nitric Oxide Activates Plasma Membrane Insertion of the Betaine/GABA Transporter in Renal Epithelial Cells Research in Cell Biology. ,vol. 2, pp. 1- 7 ,(2014)
Myeong Soo Lee, Myung-Sunny Kim, Soo Young Park, Chang-Won Kang, Effects of betaine on ethanol-stimulated secretion of IGF-I and IGFBP-1 in rat primary hepatocytes: Involvement of p42/44 MAPK activation World Journal of Gastroenterology. ,vol. 12, pp. 1718- 1722 ,(2006) , 10.3748/WJG.V12.I11.1718
A Yamauchi, S Uchida, H M Kwon, A S Preston, R B Robey, A Garcia-Perez, M B Burg, J S Handler, Cloning of a Na(+)- and Cl(-)-dependent betaine transporter that is regulated by hypertonicity. Journal of Biological Chemistry. ,vol. 267, pp. 649- 652 ,(1992) , 10.1016/S0021-9258(18)48543-2
N.C. Danbolt, K.P. Lehre, Y. Dehnes, F.A. Chaudhry, L.M. Levy, LOCALIZATION OF TRANSPORTERS USING TRANSPORTER-SPECIFIC ANTIBODIES Methods in Enzymology. ,vol. 296, pp. 388- 407 ,(1998) , 10.1016/S0076-6879(98)96028-1
Q.R. Liu, B. López-Corcuera, S. Mandiyan, H. Nelson, N. Nelson, Molecular characterization of four pharmacologically distinct gamma-aminobutyric acid transporters in mouse brain [corrected]. Journal of Biological Chemistry. ,vol. 268, pp. 2106- 2112 ,(1993) , 10.1016/S0021-9258(18)53968-5
B Lopez-Corcuera, Q.R. Liu, S Mandiyan, H Nelson, N Nelson, Expression of a mouse brain cDNA encoding novel gamma-aminobutyric acid transporter. Journal of Biological Chemistry. ,vol. 267, pp. 17491- 17493 ,(1992) , 10.1016/S0021-9258(19)37067-X
Yun Zhou, Silvia Holmseth, Caiying Guo, Bjørnar Hassel, Georg Höfner, Henrik S. Huitfeldt, Klaus T. Wanner, Niels C. Danbolt, Deletion of the γ-Aminobutyric Acid Transporter 2 (GAT2 and SLC6A13) Gene in Mice Leads to Changes in Liver and Brain Taurine Contents Journal of Biological Chemistry. ,vol. 287, pp. 35733- 35746 ,(2012) , 10.1074/JBC.M112.368175