In-vitro prediction of clinical response to chemotherapy in childhood acute leukaemia. I. Combination of daunorubicin, vincristine and prednisolone.

摘要: Summary. An in-vitro test of drug sensitivity has been performed on leukaemic blast cells obtained from eight children 11 occasions. The depends upon the per cent survival during short-term culture when exposed to appropriate concentrations Daunorubicin, Vincristine and Prednisolone, singly or in combination. results showed a satisfactory correlation with subsequent in-vivo tumoricidal effect Daunorubicin combination Vincristine, would appear have practical predictive value for selecting therapy such patients.