ACUTE LYMPHOBLASTIC LEUKÆMIA TREATED WITH A COMBINATION OF PREDNISONE, VINCRISTINE, AND RUBIDOMYCIN: Value of Pathogen-free Rooms

摘要: Abstract A combination of prednisone, vincristine, and 'Rubidomycin' was given to 11 children with untreated acute lymphoblastic leukaemia, complete remissions were obtained in all cases. The quality the striking, detailed investigation detect persisting leukaemic cells—consisting leucoconcentration, examination marrow from six different sites, cerebrospinal fluid, estimation ornithine-carbamyl-transferase levels—was negative 9 out same 5 leukaemia during their first or second relapse induced 4 Detailed 3 adults treated passed into remission, 2 these cases negative. This drug thus represent a striking advance treatment primary because both high frequency remissions—that is, reduction leukaemic-cell population. Owing rapidity which are induced, neurological side-effects vincristine cardiac effects rubidomycin can be avoided. In complicating lymphosarcoma only 6 patients treated. Use this is commonly complicated by myeloid aplasia; but infectious complications avoided if patient placed pathogen-free room. bone-marrow aplasia transitory, recovery sufficiently allow subsequent maintenance chemotherapy instituted.