ras Gene mutations and expression of Ras signal transduction mediators in gastric adenocarcinomas.
作者： Woong Shick Ahn , Robert A. Robinson , Sonya Y. Park , Chang Suk Kang , Jinyoung Yoo
DOI: 10.1043/0003-9985(2002)126<1096:RGMAEO>2.0.CO;2
关键词:
摘要: Abstract Objective.—To investigate ras gene alteration in human gastric adenocarcinomas and its potential relationship to signal transduction mediators. Design.—Genomic DNA from 104 tumors were analyzed by sequencing of polymerase chain reaction–amplified products for the presence mutations. All samples further investigated with use immunohistochemical analysis ERK1 ERK2. Setting.—Tertiary care teaching hospital. Patients.—Seventy patients a Korean population 34 Midwestern US composed white Americans African Americans. Results.—Fifteen (14%) positive either H-ras or K-ras mutation: 9 (13%) 70 6 (18%) patients. Seven (78%) mutated all (100%) intestinal-type lesions. Either and/or ERK2 was overexpressed 68 (65%). No association established between mutations overexpression ERK1/2. Howeve...
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