TTV Viral Load As a Marker for Immune Reconstitution After Initiation of HAART in HIV-Infected Patients
作者： Madsen Chris D. , Eugen-Olsen Jesper , Kirk Ole , Parner Jan , Kaae Christensen Jens
DOI: 10.1310/8C94-VYPQ-NG1H-4CNW
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摘要: AbstractPurpose: To investigate whether TT virus (TTV) viral load may be used as a surrogate marker for functional immune reconstitution in HIV-infected patients receiving highly active antiretroviral therapy (HAART). Method: Fifteen protease inhibitor-naIve were included longitudinal study. From each patient, three serum samples taken before HAART initiation and during analyzed. TTV was detected by polymerase chain reaction (PCR) quantitated competitive PCR. heterogeneity determined restriction fragment length polymorphisms (RFLPs) sequencing. Results: All 15 positive. No significant change HIV RNA or observed at the time points initiation. Even though lead to an immediate reduction (p = .0001), .0002) not until after 3-5 months of HAART. Four d...
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