Lipoprotein(a) and the Atherothrombotic Process: Mechanistic Insights and Clinical Implications

摘要: Although many epidemiologic studies have pointed at an association between plasma levels of lipoprotein(a) (Lp(a)) and cardiovascular risk, the data obtained been conflicting because a number factors, particularly those dealing with storage, lack assay standardization, population sample size, age, gender, ethnic variations, variable disease endpoints. Moreover, attention has primarily focused on whole Lp(a), relatively less emphasis its constituent apolipoprotein(a) apolipoprotein B100-containing lipoprotein, mainly low-density lipoprotein (LDL), to which is linked. According recent studies, small-size isoforms may represent risk factor either by themselves or synergistically Lp(a) concentration. density properties LDL moiety impact pathogenicity. It also become apparent that can be modified oxidative events action lipolytic proteolytic enzymes generation products exhibit atherothrombogenic potential. The role O-glycans linked inter-kringle linkers emerging. This information raising awareness pleiotropic functions opening new vistas pathogenetic mechanisms whose knowledge essential for developing rational therapies against this complex pathogen.