Protective Effect of Recombinant Human Granulocyte Colony-Stimulating Factor (rG-CSF) against Various Microbial Infections in Neutropenic Mice
作者： Masahiko Matsumoto , Shuzo Matsubara , Takashi Matsuno , Masayoshi Ono , Takeshi Yokota
DOI: 10.1111/J.1348-0421.1990.TB01054.X
关键词:
摘要: Protective effect of recombinant human granulocyte colony-stimulating factor (rG-CSF) on microbial infections was studied in cyclophosphamide (CPA)-induced neutropenic mice. The mice showed severely decreased resistance against systemic Pseudomonas aeruginosa, Escherichia coli, Serratia marcescens, Staphylococcus aureus, and Candida albicans. When such were injected subcutaneously with rG-CSF four consecutive days beginning the day after CPA injection, anti-microbial restored to level that normal anti-infective dose-dependent 50% effective doses (ED50) various tested 1-10 micrograms/kg/day. results suggest is useful for protection patients from infections.
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