Antidepressant-Induced Neurogenesis in the Hippocampus of Adult Nonhuman Primates

摘要: New neurons are generated in the adult hippocampus of many species including rodents, monkeys, and humans. Conditions associated with major depression, such as social stress, suppress hippocampal neurogenesis rodents primates. In contrast, all classes antidepressants stimulate neuronal generation, behavioral effects these medications abolished when is blocked. These findings hypothesis that induction a necessary component mechanism action antidepressant treatments. To date, on newborn have been reported only tree shrews. This study examines whether increased nonhuman primates after treatment. Adult monkeys received repeated electroconvulsive shock (ECS), which animal analog therapy (ECT), most effective short-term antidepressant. Compared control conditions, ECS robustly precursor cell proliferation subgranular zone (SGZ) dentate gyrus monkey hippocampus. A majority precursors differentiated into or endothelial cells, while few matured glial cells. The ECS-mediated was accompanied by immunoreactivity for neuroprotective gene product BCL2 (B chronic lymphocytic lymphoma 2) SGZ. interventions were not death injury. demonstrates capable inducing primate supports possibility produce similar alterations human brain.