Type III effector VopC mediates invasion for Vibrio species.

摘要: Summary Vibrio spp. are associated with infections caused by contaminated food and water. A type III secretion system (T3SS2) is a shared feature of all clinical isolates V. parahaemolyticus some V. cholerae strains. Despite its being responsible for enterotoxicity, no molecular mechanism has been determined the T3SS2-dependent pathogenicity. Here, we show that although typically thought as extracellular pathogens, T3SS2 mediates host cell invasion, vacuole formation, replication intracellular bacteria. The catalytically active effector VopC critical T3SS2-mediated invasion. There other marine bacteria encoding homologs T3SS; therefore, predict these also likely to use T3SS-mediated invasion part their pathogenesis mechanisms. These findings suggest new paradigm pathogenicity modify our view roles T3SS effectors translocated during infection.