Genetic effects of 2-methoxyethanol and bis(2-methoxyethyl)ether.
作者： D.B. McGregor , M.J. Willins , P. McDonald , M. Holmström , D. McDonald
DOI: 10.1016/0041-008X(83)90106-0
关键词:
摘要: 2-Methoxyethanol and bis(2-methoxyethyl)ether were subjected to the following assays for genetic toxicity: Ames' test, unscheduled DNA synthesis (UDS) assay in human embryo fibroblasts, sex-linked recessive lethal (SLRL) test Drosophila, dominant male rats, bone marrow metaphase analysis female sperm abnormality mice. In vivo animals exposed atmospheric concentrations of 25 or 500 ppm 2-methoxyethanol 250 1000 bis(2-methoxyethyl)ether. Point mutations UDS fibroblasts not increased by either compound, while SLRL gave ambiguous results which deserve further investigation. Chromosomal aberration frequencies rat marrow, but there was evidence from tests that both compounds have profound effects upon fertility during meiotic phase. Pregnancy frequency greatly reduced preimplantation losses large. addition, postimplantation losses. Sperm abnormalities mice compounds, particularly These on reproductive cells confined higher compounds. It concluded weak mutagenic strong antifertility described here are important safety evaluation these ethylene glycol ethers.
elsevier.com
sci-hub.se 参考文章(13)
Wegman Dh, Ohi G, Transcutaneous ethylene glycol monomethyl ether poisoning in the work setting. Journal of Occupational and Environmental Medicine. ,vol. 20, pp. 675- 676 ,(1978)
F. A. Patty, Patty's industrial hygiene and toxicology Wiley. ,(1978)
Bruce N. Ames, Joyce McCann, Edith Yamasaki, Methods for detecting carcinogens and mutagens with the salmonella/mammalian-microsome mutagenicity test Mutation Research. ,vol. 31, pp. 347- 364 ,(1975) , 10.1016/0165-1161(75)90046-1
A. J. Wyrobek, W. R. Bruce, Chemical induction of sperm abnormalities in mice. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 72, pp. 4425- 4429 ,(1975) , 10.1073/PNAS.72.11.4425
R MILLER, R CARREON, J YOUNG, M MCKENNA, Toxicity of Methoxyacetic Acid in Rats Toxicological Sciences. ,vol. 2, pp. 158- 160 ,(1982) , 10.1016/S0272-0590(82)80039-0
R.R. Miller, E.A. Hermann, P.W. Langvardt, M.J. McKenna, B.A. Schwetz, Comparative metabolism and disposition of ethylene glycol monomethyl ether and propylene glycol monomethyl ether in male rats Toxicology and Applied Pharmacology. ,vol. 67, pp. 229- 237 ,(1983) , 10.1016/0041-008X(83)90229-6
K RAO, S COBELGEARD, J YOUNG, T HANLEYJR, W HAYES, J JOHN, R MILLER, Ethylene glycol monomethyl ether II. Reproductive and dominant lethal studies in rats. Toxicological Sciences. ,vol. 3, pp. 80- 85 ,(1983) , 10.1016/S0272-0590(83)80060-8
Kasuke Nagano, Eiki Nakayama, Hisao Oobayashi, Tsutomu Yamada, Hidemi Adachi, Tomoshi Nishizawa, Harumi Ozawa, Momoko Nakaichi, Hirokazu Okuda, Kyoko Minami, Kazunori Yamazaki, Embryotoxic effects of ethylene glycol monomethyl ether in mice Toxicology. ,vol. 20, pp. 335- 343 ,(1981) , 10.1016/0300-483X(81)90040-8
Diana Anderson, Douglas B. McGregor, Terry M. Weight, The relationship between early deaths and implants in control and mutagen-treated CD-1 mice in dominant lethal assays Mutation Research. ,vol. 81, pp. 187- 196 ,(1981) , 10.1016/0027-5107(81)90033-6
Jana Kratochvilova, Evaluation of pre-implantation loss in dominant-lethal assay in the mouse Mutation Research/Environmental Mutagenesis and Related Subjects. ,vol. 54, pp. 47- 54 ,(1978) , 10.1016/0165-1161(78)90134-6