Assessment of the U.S. Environmental Protection Agency methods for identification of hazards to developing organisms, Part I: The reproduction and fertility testing guidelines.

摘要: Background Successful reproduction depends on the coordination of many processes, particularly normal development and subsequent maturation sexual organs. The Food Quality Protection Act 1996 mandates that U.S. Environmental Agency must protect infants children from effects toxins, including those affect reproductive system. Therefore, finds itself at a critical juncture to make sure methods it requires for toxicity testing, Health Effects Test Guidelines or Series 870 Guidelines, are adequate determine possible children. Methods Results We found two testing protocols included in core guidelines assess toxicological developing animals. This article aims provide detailed analysis Reproduction Fertility Guideline. An accompanying assesses Developmental Toxicity Testing conducted this basis whether test would yield information needed adequately risk Conclusions Our concludes given limitations inherent fertility during development, is necessary include safety factor assessment chemicals. action will fulfill mandate expressed FQPA environmental hazards.Am. J. Ind. Med. 35:543‐553, 1999. r 1999 Wiley-Liss, Inc.