High-mobility group protein box1 expression correlates with peritumoral macrophage infiltration and unfavorable prognosis in patients with hepatocellular carcinoma and cirrhosis

摘要: High-mobility group protein box1 (HMGB1) is a pivotal factor in the development and progression of many types tumor. Its role hepatocellular carcinoma (HCC), especially its correlation with intratumoral peritumoral macrophage infiltration, remains obscure. We analyzed potential roles prognostic value HMGB1 explored between infiltration HCC using clinical samples. reviewed clinicopathological follow-up data on cohort 149 patients complicated Hepatitis B-related cirrhosis. measured expression CD68 tumoral liver tissues after curative resection assessed impacts tumor-associated (TAM) count clinicopathologic characteristics, overall survival (OS), recurrence-free (RFS). Ninety-four had elevated 59 expression, compared to only 4 36 pateints B virus (HBV)-negative without cirrhosis (p < 0.001). The levels were correlated tumor invasiveness, BCLC stage, recurrence. degree TAM was higher high than low There no significant difference expression. Kaplan-Meier analysis showed that overexpression associated poor OS, but not RFS. High HMGB1expression count, which positively size independent factors for OS (p < 0.001 p = 0.017, respectively) RFS (p = 0.002 p = 0.024, respectively). Multivariate analyses indicated (p = 0.014) (p = 0.037), as well differentiation (p = 0.026), be HCC, suggesting might show promise new biomarker predict progression.