Artemether-lumefantrine and liver enzyme abnormalities in non-severe Plasmodium falciparum malaria in returned travellers: a retrospective comparative study with quinine-doxycycline in a Portuguese centre.

摘要: Artemisinin-based therapy is the current standard treatment for non-severe malaria due to Plasmodium falciparum. The potential asymptomatic liver toxicity of this and its implication in clinical practice currently unknown. aim study assess hepatic function patients treated with a three-day artemisinin-based regimen compare it quinine-doxycycline regimen. Retrospective comparative returned adult travellers admitted P. falciparum malaria. Fifty-seven were included: 19 38 therapy. During treatment, when compared group, artemisinin-lumefantrine group presented higher proportion significant enzyme abnormalities (42 vs. 5%, p < 0.01) peak value aspartate aminotransferase (131 64 U/L, alanine (99 75 U/L, p = 0.05). None was symptomatic, there no interruptions all achieved cure. Treatment uncomplicated might cause first days treatment. Nevertheless, these seem be harmless, self-limited.