Brains, Genes, and Primates

摘要: One of the great strengths mouse model is wide array genetic tools that have been developed. Striking examples include methods for directed modification genome, and regulated expression or inactivation genes. Within neuroscience, it now routine to express reporter genes, neuronal activity indicators, opsins in specific types mouse. However, there are considerable anatomical, physiological, cognitive, behavioral differences between human that, some areas inquiry, limit degree which insights derived from can be applied understanding neurobiology. Several recent advances brought into reach goal applying these primate brain. Here we describe advances, consider their potential advance our brain disorders, discuss bioethical considerations, what will needed move forward.