Meta-analysis: glutathione S-transferase T1 null allele is associated with gastric cancer risk.

摘要: Allelic variant within genes encoding glutathione S-transferase T1 (GSTT1) has been suggested to be a possible risk factor of gastric cancer, but previous studies provide controversial results. This study aimed assess the effects GSTT1 polymorphism on cancer by means meta-analysis. We included published relationship between null allele and after searching electronic databases. A meta-analysis was conducted calculating pooled odds ratios (OR) 95% confidence intervals (95% CI). Forty-two with total 8,203 cases 13,866 controls were into this When all 42 meta-analysis, there significant association (OR = 1.24, CI 1.14-1.36, P < 0.00001). Sensitivity analysis excluding individual showed that no effect OR CI. After low quality, still 1.13-1.36, In subgroup analysis, in both Europeans Asians. There publication bias Our results suggest is associated increased cancer.