Gastric carcinogenesis: Possible role of polymorphisms of GSTM1, GSTT1, and GSTP1 genes.
作者： Shweta Tripathi , Ujjala Ghoshal , Uday C. Ghoshal , Balraj Mittal , Narendra Krishnani
DOI: 10.1080/00365520701742930
关键词:
摘要: Objective. Although Helicobacter pylori infection is associated with gastric cancer (GC), only 1% of patients develop a malignancy, which suggests role host genetic factors. The aim this study was to investigate the polymorphisms GSTM1, GSTT1, and GSTP1 genes, encode for carcinogen-detoxifying enzymes, in mutagenesis. Material andmethods. Genotyping GSTT1 GSTM1 done using PCR, while PCR-RFLP (polymerase chain reaction-restriction fragment length polymorphism) used genotyping 76 neoplasm (GN), 67 non-ulcer dyspepsia (NUD), 44 peptic ulcer (PU), 100 healthy controls (HC). Results. population included: GN (intestinal 40 (53%), diffuse 26 (34%), primary lymphoma 8 (11%) unclassified 2 (2%)), PU (duodenal (DU) 33 (75%), (GU) 10 (23%), both DU 1 (2%)). null genotype (GSTT1*0) more common (30/76 (40%)) than those (5/44 (11%);...
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