The Association between GSTM1, GSTT1 Genetic Variants and Gastric Carcinoma Susceptibility in Chinese: A Systematic Review Article.

摘要: Background: Glutathione S-transferases ( GSTs ) have been investigated as potential carcinoma susceptible genes. However, the relationship between GSTM1 , GSTT1 variants and gastric (GC) risk has controversial in Chinese population. Methods: A comprehensive literature search strategy (PubMed, Biomedical Database, National Knowledge Infrastructure, Wan fang etc.) was launched. Crude odds ratios (ORs) confidence intervals (95% CI) were applied to estimate strength of association. Results: Significant associations genetic polymorphisms GC evidenced under random-effects model (OR =1.56, 95% CI: 1.39 1.76, I 2 =50.7%, P <0.0001; OR =1.24, 1.10 1.39, =43.6%, =0.014; GSTM1-GSTT1 =1.51, 1.26 1.81, =59.7%, =0.004). The pooled ORs not qualitatively changed when any single study omitted by sensitivity analysis. Conclusion: Our results indicated an increased population with null genotype dual genotype. Further multi-center studies are needed investigate gene-gene gene-environment interactions on susceptibility GC.