Osmoregulatory and tegumental ultrastructural damages to protoscoleces of hydatid cysts Echinococcus granulosus induced by fungal endophytes

摘要: Characteristic ultrastructural changes were observed when protoscoleces of hydatid cysts Echinococcus granulosus was treated with extract endophytic fungi Eupenicillium and Chaetomium sp. isolated from Azadirachta indica Piper longum plants respectively. A sharp decrease in viability after 6 h incubation fungal extracts. The included rosteller disorganization, loss hooks shedding the microtriches scolex region. formation digitiform projections on tegument layer which, increased size as prolong get burst, leading to a osmoregulatory damage into tegumental layers parasite. This damages caused turgidity due leakage cell contents, which might be major cause mortality parasites. It is remarkable, since very similar type some pyrazinoisoquinoline derivatives, praziquantel. Our initial results indicate that spp. are having significant anti-cestodal activity have selective layer. Further chemical prospection required through rigorous bioassay guided fractionation coupled robust high resolution mass spectrometric analysis final stereo-structures responsible for parasiticidal activity. strain selection outcome will serve platform isolation characterization new drug lead can useful tailoring novel, safe effective anthelmintics.