Association Between Tissue Inhibitor of Metalloproteinase-3 Gene Methylation and Gastric Cancer Risk: A Meta-Analysis.
作者： Jinghua Cao , Zhenfeng Li , Lijuan Yang , Chengxia Liu , Xiying Luan
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摘要: Background: The tumor suppressor gene tissue inhibitor of metalloproteinase-3 (TIMP-3) has been reported to be frequently and significantly downregulated in gastric cancer, its downregulation is correlated with hypermethylation promoter region. However, the association between TIMP-3 methylation cancer risk remains unclear. Aim: In this study, we assessed relationship by performance a meta-analysis. Methods: Relevant studies were identified comprehensive literature search using PubMed, Embase, Web Science databases. strength was odds ratio (OR) corresponding 95% confidence interval (CI). heterogeneity among tested Q-statistics I2 metric. publication bias examined Begg's funnel plots Egger's linear regression test. Results: A total 1096 subjects from eight st...
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