Causes and Clinical Features of Infertile Men With Nonobstructive Azoospermia and Histopathologic Diagnosis of Hypospermatogenesis

摘要: Objective To analyze the causes and clinical features of infertile men with nonobstructive azoospermia hypospermatogenesis (HS). Materials Methods This retrospective cohort study included 100 patients HS 8 obstructive normal spermatogenesis. The severity was subdivided into 3 groups (mild, moderate, severe) based on spermatogenic score. Data history, physical findings, serum hormone profiles, genetic studies, sperm retrieval rate were collected. Whole genome DNA methylation analysis microarray mRNA expression used to identify candidate genes dysregulation in HS. Results Thirty-two (32%) had at least 1 prior/current testicular insults 13 (13%) anomalies. Fifty-five (55%) categorized as idiopathic Patients mild a higher frequency insults, severe significantly Sperm 100%, 88.4% for mild, HS, respectively. Four sterility-related genes, including BOLL , DDX4 HORMAD1 MAEL found have increased CpGs promoter regions decreased expressions testis. Conclusion are complex multifactorial. main prior or current chromosomal More than half With high throughput analysis, dysregulations believed be associated