Altered expression of insulin receptor types A and B in the skeletal muscle of non-insulin-dependent diabetes mellitus patients.
作者： L. Mosthaf , B. Vogt , H. U. Haring , A. Ullrich
关键词:
摘要: The human insulin receptor exists in two isoforms, HIR-A and HIR-B, which are generated by alternative splicing of a primary gene transcript differ 12-amino acid insertion sequence the alpha-subunit. isoforms bind with different affinities differentially expressed tissues. We report here tissue-specific alteration RNA splice pattern non-insulin-dependent diabetes mellitus (NIDDM) patients. Whereas skeletal muscle healthy individuals contains exclusively high-affinity HIR-A-encoding RNA, we consistently find low-affinity HIR-B expression NIDDM tissue at levels similar to HIR-A.
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sci-hub.se 参考文章(30)
L. Mosthaf, K. Grako, T. J. Dull, L. Coussens, A. Ullrich, D. A. McClain, Functionally distinct insulin receptors generated by tissue-specific alternative splicing The EMBO Journal. ,vol. 9, pp. 2409- 2413 ,(1990) , 10.1002/J.1460-2075.1990.TB07416.X
B Obermaier-Kusser, M F White, D E Pongratz, Z Su, B Ermel, C Muhlbacher, H U Haring, A defective intramolecular autoactivation cascade may cause the reduced kinase activity of the skeletal muscle insulin receptor from patients with non-insulin-dependent diabetes mellitus. Journal of Biological Chemistry. ,vol. 264, pp. 9497- 9504 ,(1989) , 10.1016/S0021-9258(18)60559-9
M.P. Klinkhamer, N.A. Groen, G.C. van der Zon, D. Lindhout, L.A. Sandkuyl, H.M. Krans, W. Möller, J.A. Maassen, A leucine-to-proline mutation in the insulin receptor in a family with insulin resistance. The EMBO Journal. ,vol. 8, pp. 2503- 2507 ,(1989) , 10.1002/J.1460-2075.1989.TB08387.X
Gerald M. Reaven, Yii-Der Ida Chen, Ann M. Coulston, Michael S. Greenfield, Clarie Hollenbeck, Claude Lardinois, George Liu, Herbert Schwartz, Insulin secretion and action in noninsulin-dependent diabetes mellitus The American Journal of Medicine. ,vol. 75, pp. 85- 93 ,(1983) , 10.1016/0002-9343(83)90258-9
R. Yamamoto-Honda, O. Koshio, K. Tobe, Y. Shibasaki, K. Momomura, M. Odawara, T. Kadowaki, F. Takaku, Y. Akanuma, M. Kasuga, Phosphorylation state and biological function of a mutant human insulin receptor Val996. Journal of Biological Chemistry. ,vol. 265, pp. 14777- 14783 ,(1990) , 10.1016/S0021-9258(18)77180-9
D.E. Moller, A. Yokota, M.F. White, A.G. Pazianos, J.S. Flier, A naturally occurring mutation of insulin receptor alanine 1134 impairs tyrosine kinase function and is associated with dominantly inherited insulin resistance. Journal of Biological Chemistry. ,vol. 265, pp. 14979- 14985 ,(1990) , 10.1016/S0021-9258(18)77212-8
D. Accili, C. Frapier, L. Mosthaf, C. McKeon, S.C. Elbein, M.A. Permutt, E. Ramos, E. Lander, A. Ullrich, S.I. Taylor, A mutation in the insulin receptor gene that impairs transport of the receptor to the plasma membrane and causes insulin-resistant diabetes. The EMBO Journal. ,vol. 8, pp. 2509- 2517 ,(1989) , 10.1002/J.1460-2075.1989.TB08388.X
T Kadowaki, C. Bevins, A Cama, K Ojamaa, B Marcus-Samuels, H Kadowaki, L Beitz, C McKeon, S. Taylor, Two mutant alleles of the insulin receptor gene in a patient with extreme insulin resistance Science. ,vol. 240, pp. 787- 790 ,(1988) , 10.1126/SCIENCE.2834824
S. I. Taylor, J. Roth, R. M. Blizzard, M. J. Elders, Qualitative abnormalities in insulin binding in a patient with extreme insulin resistance: decreased sensitivity to alterations in temperature and pH Proceedings of the National Academy of Sciences of the United States of America. ,vol. 78, pp. 7157- 7161 ,(1981) , 10.1073/PNAS.78.11.7157
A. Ullrich, J. R. Bell, E. Y. Chen, R. Herrera, L. M. Petruzzelli, T. J. Dull, A. Gray, L. Coussens, Y.-C. Liao, M. Tsubokawa, A. Mason, P. H. Seeburg, C. Grunfeld, O. M. Rosen, J. Ramachandran, Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes Nature. ,vol. 313, pp. 756- 761 ,(1985) , 10.1038/313756A0