Coordination and communication between the p53 and IGF-1–AKT–TOR signal transduction pathways

作者: Arnold J Levine , Zhaohui Feng , Tak W Mak , Han You , Shengkan Jin

DOI: 10.1101/GAD.1363206

关键词:

摘要: Over the past 10 years the signal transduction networks for p53, IGF-1-AKT, and TOR pathways have been assembled in worms, flies, and mammals, and their functions elucidated. In …

参考文章(77)
Kui Lin, Honor Hsin, Natasha Libina, Cynthia Kenyon, Regulation of the Caenorhabditis elegans longevity protein DAF-16 by insulin/IGF-1 and germline signaling. Nature Genetics. ,vol. 28, pp. 139- 145 ,(2001) , 10.1038/88850
Binhua P. Zhou, Yong Liao, Weiya Xia, Yiyu Zou, Bill Spohn, Mien-Chie Hung, HER-2 / neu induces p53 ubiquitination via Akt-mediated MDM2 phosphorylation Nature Cell Biology. ,vol. 3, pp. 973- 982 ,(2001) , 10.1038/NCB1101-973
Peter Blume-Jensen, Tony Hunter, Oncogenic kinase signalling. Nature. ,vol. 411, pp. 355- 365 ,(2001) , 10.1038/35077225
Bert Vogelstein, David Lane, Arnold J. Levine, Surfing the p53 network Nature. ,vol. 408, pp. 307- 310 ,(2000) , 10.1038/35042675
Leonard Guarente, Cynthia Kenyon, Genetic pathways that regulate ageing in model organisms Nature. ,vol. 408, pp. 255- 262 ,(2000) , 10.1038/35041700
Arnold J. Levine, Shengkan Jin, The p53 functional circuit. Journal of Cell Science. ,vol. 114, pp. 4139- 4140 ,(2001) , 10.1242/JCS.114.23.4139
Lina I. Yoo, Daniel C. Chung, Junying Yuan, LKB1 — A master tumour suppressor of the small intestine and beyond Nature Reviews Cancer. ,vol. 2, pp. 529- 535 ,(2002) , 10.1038/NRC843
Julian J. Lum, Daniel E. Bauer, Mei Kong, Marian H. Harris, Chi Li, Tullia Lindsten, Craig B. Thompson, Growth factor regulation of autophagy and cell survival in the absence of apoptosis Cell. ,vol. 120, pp. 237- 248 ,(2005) , 10.1016/J.CELL.2004.11.046
Ann M. Bode, Zigang Dong, Post-translational modification of p53 in tumorigenesis Nature Reviews Cancer. ,vol. 4, pp. 793- 805 ,(2004) , 10.1038/NRC1455
Leif W Ellisen, Kate D Ramsayer, Cory M Johannessen, Annie Yang, Hideyuki Beppu, Karolina Minda, Jonathan D Oliner, Frank McKeon, Daniel A Haber, REDD1, a Developmentally Regulated Transcriptional Target of p63 and p53, Links p63 to Regulation of Reactive Oxygen Species Molecular Cell. ,vol. 10, pp. 995- 1005 ,(2002) , 10.1016/S1097-2765(02)00706-2