The lung in rheumatoid arthritis, cause or consequence?

摘要: PURPOSE OF REVIEW Recent discoveries implicate the lungs as a possible extra-articular mucosal site for initiating rheumatoid arthritis-associated immunity. RECENT FINDINGS Individuals at risk developing arthritis and patients with early untreated show signs of lung involvement on high-resolution computer tomography. Rheumatoid antibodies are present in respiratory complains such bronchiectasis unexplained dyspnea even absence joint disease might predict future development these patients. detected sputum individuals but not yet having disease. Signs bronchial inflammation germinal center formation local production have been described arthritis. Shared antigenic targets identified characterized joints SUMMARY findings support an important role place were induced by external triggers (such smoking) leads to tolerance break generation arthritis-specific immunity already before onset only secondary targeting joints.