Modulation by Retinoic Acid of Spontaneous and Benzo(A)Pyrene-Induced C-Ha-Ras Expression
作者： Devaki Nandan Sadhu , Kenneth Ramos
DOI: 10.1007/978-1-4615-2984-2_24
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摘要: The effects of retinoic acid on the expression Ha-ras gene were studied in transformed rat hepatoma cells (H4IIE) and aortic smooth muscle (ASMC) treated with benzo(a)pyrene (30 µM) vitro. In H4IIE cells, a dose- dependent increase steady state mRNA levels was observed upon exposure to for 24 hr. Exposure ASMC 10 µM under similar experimental conditions also associated increased expression. contrast, (1 inhibited benzo(a)pyrene-induced ASMC. These results suggest that modulates spontaneous carcinogen-induced differential manner.
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