Training-induced elevations in extracellular lactate in hippocampus and striatum: Dissociations by cognitive strategy and type of reward.

摘要: Recent evidence suggests that astrocytes convert glucose to lactate, which is released from the and supports learning memory. This report takes a multiple memory perspective test role of in cognition using real-time lactate measurements during Extracellular levels hippocampus or striatum were determined with biosensors while rats place (hippocampus-sensitive) response (striatum-sensitive) versions T-mazes. In first experiment, trained on tasks locate food reward. increased beyond those feeding controls training but not training. However, striatal did increase when either version maze. Because ingestion itself blood brain levels, contribution may have confounded measures. Therefore, we conducted second similar experiment water as A very different pattern responses emerged was used task First, provision result large increases levels. Moreover, extracellular learning, whereas differ across tasks. The findings two experiments suggest relative engagement dissociates only by also reward type. divergent under conditions reflect ethological constraints tied foraging for water.