Effects of lentivirus-mediated CREB expression in the dorsolateral striatum: Memory enhancement and evidence for competitive and cooperative interactions with the hippocampus

摘要: Neural systems specialized for memory may interact during formation or recall, and the results of interactions are important determinants how control behavioral output. In two experiments, we used lentivirus-mediated expression transcription factor CREB (LV-CREB) to test if localized manipulations cellular plasticity influence between hippocampus dorsolateral striatum. Experiment 1, tested hypothesis that infusion LV-CREB in striatum facilitates response learning, impairs place learning. had no effect on but impaired memory; a finding consistent with competition hippocampus. 2, cue contextual fear conditioning. enhanced learning and, contrast our prediction, also conditioning, cooperative interaction Overall, current experiments demonstrate (1) increases levels protein locally, (2) does not alter acquisition place, response, cue, (3) (4) Taken together, present provide evidence can enhance cause both competitive