The Granule Exocytosis Model for Lymphocyte Cytotoxicity and Its Relevance to Target Cell DNA Breakdown

摘要: The granule exocytosis model for lymphocyte cytotoxicity was proposed some years ago (Henkart and Henkart, 1982, 1985) has become generally accepted as one pathway which cytotoxic lymphocytes use to kill target cells (Krahenbuhl Tschapp, 1991). is appealing because it can account most of the classically known properties cytotoxicity, utilizes a basic process well cell biology: regulated protein secretion et al., 1987b). Indeed, remains only well-defined accounts rapid, lymphocyte-mediated death in vitro. However, there remain questions whether major seems likely that T (CTL) sometimes when this inoperative (Ostergaard 1987; Trenn 1987).