Ia antigens in serum during different murine infections.

摘要: There exists in the mouse a family of I-region-controlled (Ia) antigens which carry carbohydrate-defined determinants. These appear serum as glycolipids and seem to be actively secreted by antigen-activated T-cells. This paper describes ability selected viral, bacterial, protozoal infections mice markedly alter levels these Ia antigens. All infectious agents examined induced substantial augmentation or suppression concentrations both. Lymphocytic choriomeningitis (LCM) virus first enhanced then suppressed during course acute infection. Enhancement occurred time ongoing replication splenic lymphoproliferation while coincided with peak cytotoxic T-cell response clearance. Listeria monocytogenes infection reduction at just after marked depletion T-cells spleen. In contrast, Brucella abortus caused significant increase 7 days postinfection, correlates appearance numbers bacteria tissues. Finally, Plasmodium yoelii, nonlethal malarial parasite stimulates prolonged proliferation, augmented levels, whereas P. berghei, lethal tends inhibit. division, secretion. Possible interpretations different results are presented.