Spectral compensation for tissue attenuation and transmit intensity in ultrasonic detection of microbubbles by harmonic method

摘要: Tissue perfusion can be assessed by harmonic imaging of microbubbles which are highly nonlinear and produce strong components as they scatter the incident ultrasound. However, magnitude also depends on pressure transmitted ultrasound attenuation intervening tissues in path. Thus, may not a reliable indicator presence or absence microbubbles, hence, tissue perfusion. Here, we propose parameter called to squared fundamental ratio (HSFR) that, under ideal conditions, completely compensates for effects transmit superior microbubble detection. In experiments, target tested is 0.01% solution water (as control). The echoes from these targets obtained with different pressures pads used compute HSFR. HSFR able separate solutions control single threshold all combinations intensity tested.